Iowa State vs. Louisiana odds: 2020 college football picks, predictions from computer model on 4-0 run

Having cancelled its season opener against South Dakota last week, No. 23 Iowa State is in for a sterner than usual Group of 5 test when Louisiana visits Saturday. Out of the Sun Belt Conference, the Ragin' Cajuns are fresh off a strong 2019 and have a potent offense again this season. But the Cyclones are also strong on the offensive side of the ball the season, which could mean plenty of points this week.

Kickoff from Jack Trice Stadium is set for noon ET. The Cyclones are 11.5-point favorites, while the over-under for total points scored is 57 in the latest Iowa State vs. Louisiana odds from William Hill. Before finalizing your Louisiana vs. Iowa State picks, make sure you check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It was a perfect 4-0 on top-rated picks in Week 1 of the 2020 college football season, including nailing Army (-3.5) with plenty of room to spare in its 42-0 blowout of MTSU. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Louisiana vs. Iowa State. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Iowa State vs. Louisiana:
• Louisiana: The over is 4-0 in the Ragin' Cajuns' last four games as an underdog.
• Iowa State: The under is 7-2-1 in the Cyclones' last 10 non-conference games.

Louisiana is coming off an 11-3 season in 2019 and returns three huge offensive weapons: quarterback Levi Lewis and running backs Elijah Mitchell and Trey Ragas. Lewis passed for 3,050 yards and 26 touchdowns last season, while Mitchell rushed for 1,147 yards and Ragas had 820 yards.

The Ragin' Cajuns ended 2019 with a bang, defeating Miami (Ohio) 27-17 in the LendingTree Bowl. It was Louisiana's first bowl win since 2014, and the program finished with a school-record 11 victories -- two more than the previous mark.

The Cyclones finished the 2019 season with a 7-6 record, but that was somewhat deceiving -- as three of the losses (Iowa, Baylor, Oklahoma) came by a combined four points and included a 33-9 loss to Notre Dame in the Camping World Bowl.

Iowa State returns quarterback Brock Purdy, who passed for 3,982 yards and 27 touchdowns to lead an offense that averaged 311.3 passing yards per game and ranked second in 2019 in the Big 12. Running back Breece Hall averaged just over 100 yards a game in his last eight outings as a freshman last season, and finished with 897 yards.

How to make Louisiana vs. Iowa State picks

SportsLine's model is leaning under on the total with Louisiana's Lewis being held to 190 passing yards and a touchdown, and Mitchell and Ragas combining for just 145 rushing yards. It also says one side of the spread cashes in almost 70 percent of simulations. You can only get the pick at SportsLine.

So who wins Louisiana vs. Iowa State? And which side of the spread hits almost 70 percent of the time? Visit SportsLine now to see which side of the Iowa State vs. Louisiana spread to jump on Saturday, all from the advanced model that is up over $3,500 on its top-rated college football spread picks, and find out.